Dr. Raja Banerjee, an Organic
Chemist, pursued research in Structural Biology
in the Department of Biophysics, Bose
Institute during his PhD dissertation, which
includes design, synthesis and conformational analysis
of short peptides using 2D-NMR as the major tool.
Prime interest was the structure-stability aspects
of short helices (especially 310–helices);
design of water-soluble, thermally stable short
model-host helical peptides, applied as scaffolds
for helical therapeutic peptidomimetics. In postdoctoral
research worked on designing short peptides to study
helix to helix (
310)
transition to understand the ‘protein folding’
in a novel perspective. Currently he is pursuing
active research in collaboration on conformational
analysis of short designed peptide motifs and metal
binding small molecule, used for therapeutic purpose.
Research interest is designing biomimic –
bioactive molecules involving construction of minimalist
version of sequences with predefined structure and
study membrane peptides.