Genetics
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| 1.5 (Theory) + 1 (Lab) = 2.5 Credit |
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Basic Genetics: genetic code and chromosome theory of inheritance |
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Prokaryotic Genetics: |
21 Lectures |
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conjugation, transduction and transformation, Host cell restriction (restriction endonucleases), Complementation, Molecular recombination, Mapping of bacterial genes, Horizontal gene transfer |
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Fungal Genetics: |
21 Lectures |
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life cycle of yeast, recombination and linkage in yeast, tetrad analysis, genetic map vs. physical map, yeast vectors, mutant hunts (forward and reverse genetics) selection and screening strategies, mating type switching, yeast two-hybrid system |
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C. elegans genetics: RNA interference |
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Mammalian genetics: |
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Mendel’s experiments, monohybrid and dihybrid cross, sexual reproduction, applications of chi square test, deviation from Mendelian segregation, linkage, genetic map, Mendelism in human genetics: pedigree analysis, dosage compensation and sex determination, inheritance characteristics of sex-linked and autosomal traits, chromosome discovery, chromosomes as physical basis of inheritance, Polytene and lampbrush chromosomes, chromosomal aberrations and genetic load, sex-linked deleterious genes, extrachromosomal/non-Mendelian inheritance (episomes, mitochondria and chloroplasts), parental imprinting |
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Medical Genetics: |
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autosomal dominant and autosomal recessive, trinucleotide-repeat diseases, genetic counseling |
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Population Genetics: |
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Variation and its modulation, effect of sexual reproduction on variation (Hardy-Weinberg Equilibrium), sources of variation, selection balanced polymorphism, random events |
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Recommended Texts: |
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G. Stent; Introduction to Molecular Genetics
M. W. Strickberger; Introduction to Genetics
Anthony J. F. Griffith; Introduction to Genetic Analysis
R. W. Old and S. B. Primrose; Principles of Gene Manipulation |
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